If your book is a children’s book, with two page spreads, yes, we can make those pages work in what are called Fixed-Format eBooks. Fixed-format books are, as of this writing, (and still, as of May, 2015, when this article was updated), device-specific. This means that a book made for the Kindle Fire device will only work on that device. It can't be used on for iBook or for Nook. A NookKids’ formatted book will only work on Nook, and so forth. Generally speaking, this format is almost always used strictly for children's books, at the time of this writing (September of 2012), although, at the time of updating, it is making increasing inroads in textbooks and cookbooks, as well as some coffee-table books. See below for some splendid examples!
Two page spreads cannot at this time be incorporated into a book that is normally formatted on the rest of its pages. This means that if your book is reflowing throughout, we cannot make a single two-page spread and insert it in the middle of the book. An ebook is either all fixed-format or all reflowable. It cannot be both mingled together.
Here, you'll see two different "fixed-format" versions of the same book. The vertical format displays "The Big Galoot," by renowned radio personality Shadoe Stevens', in Kindle Fixed-Format for the Kindle Fire device. The red "text" box is a pop-up text box that the child can swipe with her finger to advance through the book, paragraph-by-paragraph or page-to-page. Below that is the same title, this time in the iBooks e-reading application on the iPad. In this view, it is rotated (the device is turned horizontally) to display a "two page spread."
Fixed Format books are expensive to make, and as stated above, are limited in usage to very specific devices. For an author to put her book on three platforms, like Amazon, Barnes & Noble and the Apple devices, she'll need 3 different versions of the same book. The results can be very spectacular, and you can embed audio in both the NookKids' books and the iBooks-versions.